Thursday night football has proven to be incredible this season, giving fans yet another must-watch matchup between the Philadelphia Eagles and New York Giants.
And, for the second straight week, all of our staff is heading into the weekend 0-1 after choosing the Eagles over the Giants.
On Sunday, the Denver Broncos (3-2) and New York Jets (0-5) will be playing the early game in London at Tottenham Hotspur Stadium (15:30 CET).
Click here for all information on the NFL's international games.
Week 6 will only include one divisional matchup (Cleveland Browns (1-4) vs. Pittsburgh Steelers (3-1), but will feature seven inter-conference games.
The AFC has been beaten down by the NFC this year, posting a 9-18 record, including a 2-5 record last week (read details here).
On Sunday night, it'll be a battle of last year's top seeds in the Detroit Lions (4-1) and Kansas City Chiefs (2-3).
Detroit boasts the No. 1 scoring offence and the No. 8 overall defence. They're coming off four straight wins after dropping their season opener. As for Kansas City, they're entering the week off a Monday night loss to the Jacksonville Jaguars (4-1) and are currently 2-3 on the year.
On Monday night, it'll be another doubleheader as the Buffalo Bills (4-1) head south to take on the Atlanta Falcons (2-2), and the Chicago Bears (2-2) travel to Landover to face the Washington Commanders (3-2).
The Houston Texans (2-3) and Minnesota Vikings (3-2) are on a bye for Week 6.
Now, let's get into our weekly picks!
Expert picks
Paul took home the crown last week after going 8-6 in what was the first rough week for all of our experts' picks.
But Miguel still holds strong in the yearly standings (excluding Thursday's game):
Miguel: 51-26-1
Paul: 47-30-1
Me: 43-34-1
Henri: 40-37-1
Here's who they picked for Week 6!
