After Week 5, the NFC is now 18-9 against AFC teams this season. The AFC finished last week winning just two of the seven inter-conference matchups and will look to bounce back this week.
Now, let's not waste any more time and get into the previews!
And be sure to check out who our experts picked this week.
Denver Broncos (-6.5) vs. New York Jets (London @ 15:30 CET)
The Broncos are coming off a big win against the Philadelphia Eagles. Meanwhile, the Jets will be seeking their first win of the season at a neutral site in London at Tottenham Hotspur Stadium.
Denver's defence has a league-leading 21 sacks through five games this season. They'll be looking to feast against a Jets offence that has allowed seven in the past two games alone.
The Broncos have held all of their opponents under 20 points in their three wins this season. However, two of those are against the Titans and Joe Burrow-less Bengals.
Last time Denver went to London was in 2021 when they beat the Jacksonville Jaguars. As for New York, they've lost their last two London matchups - in 2024 against the Minnesota Vikings, in 2021 against the Atlanta Falcons.
Seattle Seahawks (-1.5) @ Jacksonville Jaguars
Seattle is coming off a last-second lost to the Buccaneers at home, while Jacksonville is playing on a short week following their Monday night win over the Chiefs.
These two teams have played each other only once this decade - in 2021 when the Seahawks smashed the Jaguars 31-7.
Both the Seahawks and Jaguars have a bottom-10 overall defence, but each have an offence that ranks in the top half of the league.
But most importantly, these two boast top-10 scoring offences, scoring a combined total of 66 points in Week 5 - more than any pair of teams facing each other this week.
The over-under is set at 47.5.
Los Angeles Chargers (-3.5) @ Miami Dolphins
Los Angeles continues to be decimated by injuries at the running back position yet again. With both Najee Harris and rookie standout Omarion Hampton out, they'll also be without left tackle Joe Alt for another week and backup tackle Trey Pipkins as well.
They're now coming off back-to-back losses where they failed to put up at least 20 points. In the first three weeks when they were 3-0, they put up 20 points or more in each respective matchup.
Even though the Dolphins are relatively healthy, minus Tyreek Hill, they've given up at least 27 points in four of their five games this season. They rank 28th in offence and 29th in defence. But their saving grace is that the Chargers have allowed the fourth-most sacks this season (17).
The over-under is set at 43.5.
Los Angeles Rams (-7.5) @ Baltimore Ravens
After an ugly loss to a rough Houston Texans team, the Ravens are going to need to saddle up as they face the league's No. 2 overall offence in the Rams.
Los Angeles is only one of two teams to average over 400 yards per game this season, while the Ravens' defence is one of two in the league to allow over 400 yards per game.
This is a nightmare matchup for a Baltimore team without Lamar Jackson for the second straight week. They signed cornerback Chauncey Gardner-Johnson, who was released by the Texans due to character issues, and traded for safety Alohi Gilman (sent Odafe Ower to the Chargers) to help boost their secondary somehow.
But if the Ravens are this much of underdogs in their own stadium, it's for a good reason. After scoring at least 30 points in each of their first three games, leading the league in scoring, they've now scored 30 points total in the past two weeks.
The over-under is set at 45.5.
Arizona Cardinals @ Indianapolis Colts (-6.5)
The Colts' No. 4 offence could be in for another treat going up against Arizona's 21st defence.
Indy being almost perfectly healthy from top to bottom, with Arizona being a little battered, is also a cause for concern for the Cardinals.
Arizona's offence is in both the bottom 10 overall and scoring. Meanwhile, Indy has only scored less than 29 points in one game this season - a loss to the Rams in which they still put up 20.
This could spell disaster for a Cardinals team that has yet to put up more than 22 points this season.
The over-under is set at 47.5.
Dallas Cowboys (-3.5) @ Carolina Panthers
Despite the Cowboys' offence being beaten with significant injuries, they've still managed to put out the league's No. 1 overall offence (No. 4 in scoring).
As for the Panthers, bottom 10 in scoring and 21st in overall offence. What's even worse is that they're tied with the Bears for the fewest sacks (5) so far this season, despite their pass defence ranking 10th.
However, there is a saving grace for the Panthers - the Cowboys also have the 32nd-ranked defence (29th in scoring). And they're coming off a win against the 29th-ranked Dolphins defence in which they put up over 400 yards and 27 points against.
The over-under is set at 48.5.
New England Patriots (-3.5) @ New Orleans Saints
New England is coming off their Sunday night upset over the Buffalo Bills as they've now won three of their last four games. Quarterback Drake Maye is finally establishing a connection with veteran wide receiver Stefon Diggs, who now has back-to-back weeks with at least 100 receiving yards.
Their team stats are mostly middle-of-the-pack for the most part, even their turnover differential is a simple -1.
As for New Orleans, they're coming off their first win of the season over the New York Giants. Much like the Patriots, their defence sits in the middle of the pack, but have forced the fourth-most turnovers (8) this season and committed the second-fewest (3).
The Saints have only scored over 20 points this season - last week (26) and in their Week 2 loss to the Niners (21).
The over-under is set at 45.5.
Cleveland Browns @ Pittsburgh Steelers (-6.5)
In the only divisional matchup of the week, fans will be seeing the 30th-ranked offence (PIT) against the No. 2 defence (CLE). On the flip side, it's not pretty.
Browns boast the 27th overall offence (t-32nd in points) against the Steelers' 28th overall defence (21st in points).
Pittsburgh is coming off their bye week, giving them two weeks to prepare for this home matchup.
The Browns haven't won a game in Pittsburgh during the regular season since 2003.
This divisional matchup's over-under is set at a very low 38.5.
Tennessee Titans @ Las Vegas Raiders (-4.5)
In a game of two of the league's worst teams outside the Jets, both have a bottom-three scoring offence this season - and their defences are equally rough.
Tennessee has the 26th-ranked defence, while the Raiders have the 25th. Las Vegas is second in the league in turnovers (10), the Titans are tied for fifth (8).
Both rank in the bottom 10 in sacks while simultaneously being in the top 10 of sacks given up. Neither the Raiders nor the Titans have scored more than 24 points in a game this season.
The over-under is set at 41.5.
San Francisco 49ers @ Tampa Bay Buccaneers (-3.5)
In our 'Spotlight Game of the Week', both teams are roughed up with a ton of injuries on offence. Tampa Bay will be without starting wide receivers Mike Evans and Chris Godwin, along with starting running back Bucky Irving.
San Fran will be without wide receivers Ricky Pearsall, Jordan Watkins, and Brandon Aiyuk, along with star tight end George Kittle for yet another week. And, of course, starting quarterback Brock Purdy.
However, the team is 3-0 with backup quarterback Mac Jones, who has led the 49ers to the No. 5 overall offence.
As for the Bucs, all four of their wins have come off game-winning drives. Now, they have the No. 8 scoring offence in all of football and the No. 11 offence.
Read here for a more in-depth breakdown for this game.
Cincinnati Bengals @ Green Bay Packers (-14.5)
Cinci is rolling with former Super Bowl MVP Joe Flacco at quarterback, despite being with the team for less than a week after trading for him.
The bad news - they're facing the Packers in Green Bay. The good news - their 32nd-ranked offence can't get any worse. They've lost three straight games by a combined score of 113-37.
Meanwhile, the Packers have the No. 4 defence and the No. 9 scoring offence.
Place your bets, ladies and gentlemen. This game's over-under is set for 44.5.
Detroit Lions @ Kansas City Chiefs (-2.5)
Sitting at 2-3, and coming into this game on a short week following their Monday night loss, the Chiefs sit in the middle of the pack across the board for team stats, including takeaways.
These aren't the dominant Chiefs of old anymore. That being said, they've put up 65 points in the past two weeks - just short of the Lions' 71.
Despite the Chiefs being home favourites, the Lions are the better team across the board. After their Week 1 blunder against the Packers, Detroit has become the No. 1 scoring offence by scoring at least 34 points in each of their past four games.
Lions wide receiver Amon-Ra St. Brown leads the league with six receiving touchdowns. Their Sonic-Knuckles running back duo of Jahmyr Gibbs and David Montgomery have each rushed for over 300 yards and four touchdowns.
The over-under is set at 51.5 - the highest of any game for Week 6.
Buffalo Bills (-4.5) @ Atlanta Falcons
The Falcons are coming off their bye week, while the Bills are coming off their first loss of the season to the Patriots. Both teams boast the league's No. 1 (ATL) and No. 2 (BUF) pass defences.
Atlanta has the No. 1 overall defence heading into Week 6 and will be up against the Bills No. 4 offence.
From what seems like a good matchup in those stat categories, Atlanta's 27th scoring offence (seventh overall) will matchup against the Bills No. 9 overall defence.
Atlanta and Buffalo both have put up at least 320 yards of offence in all of their games this season.
However, two stats stand out - the Falcons have allowed the second-fewest sacks (3) and both teams have a +1 turnover differential.
The over-under is set for 49.5.
Chicago Bears @ Washington Commanders (-4.5)
In the final game of the week, the injury-riddled Commanders' offence will host a relatively healthy Bears team coming off their bye week.
The Commanders will be without wide receivers Terry McLaurin and Noah Brown for the matchup, with Deebo Samuel questionable as he deals with a heel injury.
Both teams pose similar offences this season, while both have bottom-10 defences. However, the Bears have forced the third-most turnovers (9) and the Commanders are tied with the elite Rams pass rush for the third-most sacks (15).
Washington's offence can still roll as they've scored 27 points in back-to-back weeks. As for Chicago, before entering their bye, they put up two wins, scoring 31 and 25 in each, respectively.
This second Monday night matchup also has its over-under set at 49.5