The 439-foot homer marked Harper's 14th of the season to give the Phillies a 3-0 lead in the bottom of the first inning.
Harper headed into Wednesday's action with a .275/.383/.509 slashline with 42 RBI and nine stolen bases.
The eight-time All-Star and two-time MVP is currently in his 14th season and his seventh with the Phillies.
Harper was originally selected with the first overall pick in the 2010 MLB Draft by the Washington Nationals, winning Rookie of the Year two seasons later at 19 years of age.
Should Harper reach 20 home runs this season, he will have hit at least 20 in 11 of his 14 seasons. The career .281 hitter also has a lifetime .909 OPS and surpassed 1,000 RBI earlier this season. He is also just one stolen base away from reaching the 150 mark.